Authoritative and state of the art the genetics of osteoporosis and metabolic bone disease offers todays endocrinologists rheumatologists and geneticists a gold standard compendium of current knowledge and thinking about the genetic disorders of bone and mineral metabolism and a sound basis for powerful new genetic therapies. The diseases covered are both single gene mendelian traits such as x linked hypophosphatemic rickets and such complex disorders as osteoporosis and pagets disease the book includes a discussion of current methodology for finding genes that predispose to metabolic bone diseases. Metabolic bone disease is an umbrella term referring to abnormalities of bones caused by a broad spectrum of disorders most commonly these disorders are caused by abnormalities of minerals such as calcium phosphorus magnesium or vitamin d leading to dramatic clinical disorders that are commonly reversible once the underlying defect has been treated. The mission of cleveland clinics center for osteoporosis and metabolic bone disease is to evaluate and treat patients with osteoporosis and other forms of diseases that affect bone osteoporosis is common about 57 million americans have osteoporosis and low bone mass about 34 million are at risk for the disease. The clinic for metabolic and genetic disorders of bone offers medical services to adult patients with a variety of bone disorders like osteoporosis osteomalacia rickets metabolic bone diseases due to abnormalities in calcium and phosphorus metabolism genetic disorders of bone such as osteogenesis imperfecta heritable defects of collagen and developmental abnormalities of bone
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