The discovery of insulin c peptide and proinsulln species differences crude insulin was extracted and isolated from dog pancreases removed 7 1 weeks after ligation of the pancreatic duct for the first time in 1921 by banting and best. Previous work on proinsulin immunoassay suggested that this prohormone but not c peptide cross reacts with insulin antiserum on the other hand in the c peptide immunoassay proinsulin but not insulin cross reacts with the antiserum up to this time therefore it has not been possible to immunoassay human proinsulin or c peptide specifically. The ss cell produces proinsulin which is then processed into c peptide and insulin c peptide and insulin are released in equal concentrations in the blood therefore c peptide and insulin levels should be a marker for ss cell function. The c peptide immunoreactivity in these patients consists of both c peptide and proinsulin the latter being largely bound to the circulating anti insulin antibodies following glucose both c peptide and proinsulin rise indicating an appropriate beta cell response to the glycemic stimulus fig 1. C peptide is a substance produced by the beta cells in the pancreas when proinsulin splits apart and forms one molecule of c peptide and one molecule of insulin insulin is the hormone that is vital for the body to use its main energy source glucose
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